Acute hepatitis after parenteral amiodarone administration.
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چکیده
منابع مشابه
Early acute hepatitis with parenteral amiodarone: a toxic effect of the vehicle?
A 72 year old white man developed acute hepatic impairment and renal failure within 24 hours of starting intravenous amiodarone for paroxysmal ventricular tachycardia. After normal initial investigations, there was a noticeable rise in serum transaminases as well as an increase in clotting times, a decrease in renal function and a thrombocytopenia. These changes returned to normal within seven ...
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During a randomized, double blind, crossover, placebo-controlled clinical trial of oral isoniazid (isonicotonic acid hydrazide, INH),’ serum cholesterol was measured during the sixth week of treatment ofboth phases ofplaeebo and the drug in five men. The ages of the patients ranged from 28 to 65 years, with a mean of 45 years. The dosage of isoniazid was 300 mg thrice daily (15 mg/kg body weigh...
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P450 3A4 (CYP3A4) and CYP2C8. The CYP3A4 isoenzyme is present in both the liver and intestines. The highly variable systemic availability of oral amiodarone may be attributed potentially to large interindividual variability in CYP3A4 activity. Amiodarone is eliminated primarily by hepatic metabolism and biliary excretion and there is negligible excretion of amiodarone or DEA in urine. Neither a...
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1 Lupon-Roses J, Simo-Canonge R, Lu-Cortez L, Permanyer-Miralda G, Allende-Mondus H. Probable early acute hepatitis with parentral amiodarone. Clin Cardiol 1986;9:225-9. 2 Pye M, Northcote RJ, Cobbe SM. Acute hepatitis after parenteral amiodarone administration. Br Heart 7 1988;59: 690-1. 3 Stephenson RNS, Nayam TH, Davies JR. Acute hepatic dysfunction following parenteral amiodarone administra...
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Note to Readers: Contributions to this column are prepared by the Institute for Safe Medication Practices Canada (ISMP Canada). The article presented here uses, with permission, information originally published in ISMP Canada Safety Bulletin 2009;9(7). Future bulletins from ISMP Canada that have particular relevance to hospital pharmacists will be published in the CSHP eBulletin, a semimonthly ...
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ژورنال
عنوان ژورنال: Heart
سال: 1988
ISSN: 1355-6037
DOI: 10.1136/hrt.59.6.690